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| CAS:178823-49-9:Tiplimotide | |
| Tiplimotide is a structurally optimized synthetic immunoregulatory short peptide. It promotes thymic T cell differentiation and maturation as well as peripheral T cell activation and proliferation, elevates cellular immune response level, bidirectionally regulates immune homeostasis and corrects immunodeficiency states. Applied in immunodeficiency, infectious immunity assistance, thymic function mechanism research and immunomodulator development. | |
| 95% / 98% / 99% | |
| N-terminal acetylation, C-terminal amidation | |
| ~850 |
| Function Tags (comma-separated) | N-terminal Modification | C-terminal Modification | |||||||
| Large peptide, no precise small-molecule formula; subject to actual batch MS | - | ~850 (theoretical) | ~7 |
| Long-term Storage Conditions | Short-term Storage Conditions | ||||
| PEP-TPL001 | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles | Stable for 2 years at 2-8℃ sealed & dry; prepare aqueous solutions freshly before use | Stable for 72 h at 4℃; stable for 1 month at -20℃ in aliquots. **Good water solubility, freely soluble in water and physiological buffer**. Terminal modifications significantly enhance enzymatic resistance. Aromatic residues prone to photooxidation | Stable for 3 years at -20℃ under dry & dark conditions |
| Applicable Research Areas (comma-separated) | ||||
| PEP-TPL001 | Terminal-modified immunoregulatory short peptide that promotes T cell activation and proliferation, enhances cellular immunity and bidirectionally regulates immune homeostasis | Tiplimotide is a structurally optimized synthetic immunoregulatory peptide. It acts on thymic lymphocytes and peripheral T cells, promotes T cell differentiation, maturation and activation, elevates CD4+/CD8+ T cell ratio and cytotoxic T cell killing activity, and enhances cellular immune response and immune surveillance function. Meanwhile, it bidirectionally regulates immune homeostasis, corrects immunodeficiency states, and improves the body's anti-infection and anti-tumor immunity. Compared with native thymic peptides, its terminal blocking and amino acid site optimization significantly improve metabolic stability with longer in vivo half-life and more defined immune activity. This molecule is widely used in research fields such as immunodeficiency models, infectious disease immune assistance, tumor immunity enhancement and thymus function mechanism. It serves as a core tool molecule for immunoregulatory mechanism research and peptide immunomodulator development. |
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